POS1249 LUNG ULTRASOUND CHANGES COMPARED WITH AUTOMATED QUANTITATIVE COMPUTED TOMOGRAPHY FOR DETECTING SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE

Background B-lines and pleural line (PL) changes represent lung ultrasound (LUS) findings for detection of systemic sclerosis-associated interstitial disease (SSc-ILD). The ≥10 cut-off was found to be closely related moderate ILD on high-resolution chest tomography (CT). Recently proposed Fairchild’s criteria PL evaluation resulted in high accuracy reproducibility a low spending time. Semi-quantitative irregularity score by Pinal-Fernandez proved superior total number detect SSc-ILD. Although several evidence-based LUS scores have been presented, there is currently lack studies involving comprehensive assessment comparing different with CT, particularly automated quantitative CT (qCT) assessment. Objectives To evaluate the qualitative SSc-ILD compared qCT Methods Consecutive SSc patients according 2013 ACR/EULAR classification underwent two certified blinded operators using 14-scans method. fulfilment were selected as findings. From point view, sum adapted from collected. scans performed over ±6 months period recorded evaluated thoracic radiologists, further processing texture analysis software. Results study population consisted 29 (Table 1). Agreement between almost perfect [Cohen’s kappa (k) 0.84] substantial (k 0.78). Both predictive presence resulting slightly more (Figure 1A). confirmed multivariate analysis, introducing confounders like age, duration, ongoing immunosuppressant therapy, current/ever smoking (Fairchild’s criteria: p 0.0003 B-line cut-off: 0.03). All significantly associated extension (p<0.05). Total correlated reticulations both ground-glass 1B C). Lung bases score, but not same site, correlate basal 1D). Conclusion This highlights reliability good systematic detection, qCT. increasingly emerging an accurate, feasible, low-cost, radiation-free pre-CT screening tool. For these reasons, standardisation appears required, order achieve its wider use clinical practice. References [1]Gutierrez M et al. Radiol Med , 2019 [2]Xie, H.Q Arthritis Res Ther [3]Tardella Medicine (Baltimore), 2018 [4]Pinal-Fernandez I Clin Exp Rheumatol, 2015 [5]Fairchild R Care Res, 2021 Table 1 Data population, software analysis. Female/male, N° (%) 26/3 (89.6/10.4) Median age (years) [quartiles] 59 [49;70] duration 8 [4;12] Diffuse/limited cutaneous disease, 20/9 (69/31) Immunosuppressive 15 (51.7) Interstitial Disease (ILD), 22 (75.9) fulfilling, 21 (72.4) cumulative B-lines, (median [quartiles]) 24 [8;57] 13 [4;22] Ground-glass (cm 3 / %) 179 [30;578]/ 3.8 [0.65;15] Reticulations 47 [28;103]/ 1.2 [0.6;5.2] 323 [70;652]/ 8.2 [1.6;19] Basal ) 191 [51;305] LUS, ultrasound; qCT, tomography; PL, line. Acknowledgements: NIL. Disclosure Interests None Declared.